To keep at a distance; to withdraw; to cease to frequent and be familiar with. Had we estranged ourselves form them in things indifferent. I thus estrange my person from her bed.

To alienate; to divert from its original use or possessor; to apply to a purpose foreign from its original or customary one. They have estranged this place, and burnt incense in it to other gods. Jeremiah 19:4.

To alienate, as the affections; to turn from kindness to indifference or malevolence. I do not know, to this hour, what it is that has estranged him from me.

To withdraw; to withhold. We must estrange our belief from what is not clearly evidenced.